抽象的

Novel in situ self-assembly nanoparticles for Pediatric drug formulations

Xiaowei Dong

Over 65% of current medications don't have commercially available pediatric formulations. Lack of pediatric formulations has led to the necessity to interrupt tablets or open capsules for administration, risking reduced efficacy and adverse effects due to inaccurate dosing. Mostly the challenges faced by limitations on doses of liquid, flexible oral solid dosage forms are preferred for pediatric formulations. The recent discoveries which got a unique platform through nanotechnology to manufacture solid granules that produce in place self-assembly nanoparticles (ISNPs) when introduced to water or other fluids (e.g. gastrointestinal fluid). The current ISNPs are lipid-based nanoparticles. We successfully applied the ISNP nanotechnology for ritonavir, lopinavir, a fixed-dose combination of lopinavir/ritonavir and a fixed-dose combination of 4 drugs. Drug-loaded ISNP granules achieved over 15% of drug loading, acceptable stability at temperature and over 90% of drug entrapment efficiency. As per the dissolution and electronic-tongue, drug-loaded ISNP granules had familiar taste to the placebo granules. As the pharmacokinetic studies moreover showed that ISNP granules has improvised the drug bioavailability and bio distribution. The overall results demonstrated that the novel ISNP nanotechnology may be a very promising platform to manufacture palatable, heat stable and versatile pediatric granules.