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Effect of short-term carvedilol therapy on salivary and plasma oxidative stress parameters and plasma glucose level in type II diabetes

Bagher Larijani, Mojgan Afshari, Fatemeh Astanehi-Asghari, Alireza Mojtahedi, Ali Rezaie, Arash Hosseinnezhad, Ramin Heshmat, Azadeh Mohammadirad and Mohammad Abdollahi

Background: Type II diabetes is associated with oxidative stress while carvedilol has been shown to have antioxidant properties, which are thought to account for the protective effects. Objective: The objective of this study was to compare the short-term effects of carvedilol versus placebo on oxidative stress status in type II diabetic patients. Methods: A total of 40 patients were randomly allocated to receive carvedilol (6.25 mg three-times daily; n = 20) or placebo (n = 20) for 2 weeks. Fasting blood sugar, hemoglobin A1c, total antioxidant capacity (ferric-reducing ability of plasma test) and lipid peroxidation (thiobarbituric acid reactive substances assay) in plasma and saliva were measured before and after the intervention. Results: No significant difference in oxidative stress status, fasting blood sugar and hemoglobin A1c was observed among the placeboand carvedilol-treated groups. Conclusion: We conclude that unlike long-term therapy, short-term therapy with carvedilol is incapable of exerting its antioxidant properties and reducing blood sugar levels.